According to the study undertaken by Astute Analytica, the Global Molecular FISH Testing Market is projected to witness a major jump in its revenue from US$ 645.2 Mn in 2021 to US$ 978.6 Mn by 2027. The market is registering a CAGR of 7.2% over the forecast period 2022-2027. Fluorescence in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes that bind to only particular parts of a nucleic acid sequence with a high degree of sequence complementarity. It was developed by biomedical researchers in the early 1980s to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific RNA targets in cells, circulating tumor cells, and tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
The market is majorly driven by factors such as increasing prevalence of genomic abnormalities & cancers and growing adoption of new techniques for molecular-based cytogenetics. Often parents of children with a developmental disability want to know more about their child's conditions before choosing to have another child. These concerns can be addressed by analysis of the parents' and child's DNA. In cases where the child's developmental disability is not understood, the cause of it can potentially be determined using FISH and cytogenetic techniques. Examples of diseases that are diagnosed using FISH include Prader-willi syndrome, Angelman syndrome, 22q13 deletion syndrome, chronic myelogenous leukemia, acute lymphoblastic leukemia, Velocardiofacial syndrome, and down syndrome. Furthermore, FISH can be used to form a diagnosis, to evaluate prognosis, or to evaluate remission of a disease, such as cancer. Treatment can then be specifically tailored. Therefore, the demand of FISH Probes in the medical sector has been increasing due to its function in analyzing biomarkers in tumor cells.
Moreover, growing adoption of new techniques for molecular-based cytogenetics is also propelling market growth. By using variations like SKY and M-FISH, new non-random genetic abnormalities can be identified as well. Spectral karyotyping or multicolor FISH is a modification of native FISH in which using the different colored sequence-specific probe each chromosome can be painted thus, chromosomal rearrangement can be encountered precisely. However, the high cost of FISH probes poses a challenge for market growth.
Segmentation Analysis
Cryo FISH technology has the highest share in the Global Molecular FISH Testing Market in 2021
Based on technology, the market is segmented into flow FISH, Q FISH, imuno FISH, cryo FISH, and Other FISH. Among these, the cryo FISH segment holds the highest market share in 2021 and is estimated to continue its dominance over the projection period. With confocal microscopy, cryo FISH technique provides increased spatial resolution, increased detection sensitivity, increased probe accessibility, and improved picture contrast.
The whole chromosome probe type holds the highest market share in 2021
In terms of probe type, the molecular FISH testing market is categorized into locus specific, centromeric repeats, and whole chromosome. The whole chromosome segment has the highest share in the Global Molecular FISH Testing Market in 2021. The whole chromosome probes are used for the multi-color FISH and spectral karyotyping. It is a mixture of probes that binds to the entire chromosome length and thus different chromosomes are colored or labeled with different colored probes.
DAPI cellular stain leads the Global Molecular FISH Testing Market in 2021
Based on cellular stains, the market is fragmented into DAPI (4,6-diamidino-2-phenylindole), acridine orange, and others. Among these, the DAPI (4,6-diamidino-2-phenylindole) segment has the highest market share in 2021 as the use of DAPI labelling permits cells to be used several times, obviating the requirement for duplicate samples.
Cancer research is the highest application segment in the molecular FISH testing market in 2021
In terms of application, the market is segmented based on cancer research, genetic diseases, and others. The cancer research segment holds the highest market share in 2021 and registers the highest CAGR over the projection period. This is due to rising prevalence of cancer across the globe. Further, FISH testing has been used to detect and better predict the course and treatment of various cancers, including lung cancer, brain cancer, ovarian cancer, colon cancer, melanoma, and others.
Clinical segment is the highest end user in the molecular FISH testing market in 2021
Clinical segment is the highest end-user segment in the molecular FISH testing market in 2021, whereas companion diagnostics have the highest CAGR over the forecast period. This is because FISH is used to diagnose congenital diseases such as Down's Syndrome and Edward's Syndrome.
North America dominates the Global Molecular FISH Testing Market
North America holds the highest share in the Global Molecular FISH Testing Market in 2021 and is further expected to continue its dominance across the projection period. This is due to the rising incidence of cancer and infectious diseases in the region. Asia Pacific registers the highest CAGR over the projection period.
Competitive Dashboard
Segmentation Overview
The following are the different segments of the Global Molecular FISH Testing Market:
By Technology segment of the Global Molecular FISH Testing Market is sub-segmented into:
By Probe Type segment of the Global Molecular FISH Testing Market is sub-segmented into:
By Cellular Stains segment of the Global Molecular FISH Testing Market is sub-segmented into:
By Application segment of the Global Molecular FISH Testing Market is sub-segmented into:
By End User segment of the Global Molecular FISH Testing Market is sub-segmented into:
By Region segment of the Global Molecular FISH Testing Market is sub-segmented into:
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