Molecular FISH Testing Market - Industry Dynamics, Market Size, And Opportunity Forecast To 2027

The Global Molecular FISH Testing Market is estimated to witness a rise in its revenue from US$ 645.2 Mn in 2021 to US$ 978.6 Mn by 2027. The market is registering a CAGR of 7.2% over the forecast period 2022-2027. Fluorescence in situ hybridization (FISH) is a ‘molecular cytogenetic technique in which using molecular probes, any type of chromosomal abnormalities can be encountered precisely by hybridization. The karyotyping takes at least 3 to 4 days to complete the entire process while the FISH method is rapid, one can get results within a day. The cell culture process is not needed for performing FISH which is one of its most important advantages. Identification of specific chromosomal abnormality, especially structural as well as numerical; chromosomal deletion, duplication, and translocation can be detected using fluorescence in situ hybridization. By using variations like SKY and M-FISH, new non-random genetic abnormalities can be identified as well.

The market is majorly driven by factors such as the increasing prevalence of genomic abnormalities & cancers and the growing adoption of new techniques for molecular-based cytogenetics. Often parents of children with a developmental disability want to know more about their child's conditions before choosing to have another child. These concerns can be addressed by analysis of the parent's and child's DNA. In cases where the child's developmental disability is not understood, the cause of it can potentially be determined using FISH and cytogenetic techniques. Examples of diseases that are diagnosed using FISH include Prader-Willi syndrome, Angelman syndrome, 22q13 deletion syndrome, chronic myelogenous leukemia, acute lymphoblastic leukemia, Velocardiofacial syndrome, and down syndrome. Furthermore, FISH can be used to form a diagnosis, evaluate prognosis, or evaluate remission of a disease, such as cancer. Treatment can then be specifically tailored. Therefore, the demand for FISH Probes in the medical sector has been increasing due to their function in analyzing biomarkers in tumor cells. Moreover, the growing adoption of new techniques for molecular-based cytogenetics is also propelling the market growth. By using variations like SKY and M-FISH, new non-random genetic abnormalities can be identified as well. Spectral karyotyping or multicolor FISH is a modification of native FISH in which using the different colored sequence-specific probe each chromosome can be painted thus, chromosomal rearrangement can be encountered precisely. However, the high cost of FISH probes poses a challenge to market growth. 

Key Insights of the Report: 

• The latest study published by Astute Analytica analyzes the Global Molecular FISH Testing Market for the study period of 2017-2027; where the historical years are 2017-2020, the base year is 2021, and the forecast period is 2022-2027.
• The research report offers a detailed study of market determinants including market drivers, restraints, opportunities, and trends; along with an attractive presentation in the form of impact analysis to gain a simpler and easy comparison view of all market determinants.
• The research study is a compilation of 16 chapters distributed across 189 pages with 49 lists of tables and 100 lists of figures.
• The various segmentations considered to analyze the market are based on technology, probe type, cellular stains, application, end-users, and region.
• The market estimates are presented in terms of value (US$ Mn)
• Along with market estimations, the market study was conducted based on various economic models such as PESTLE analysis and Porter’s five force models.
• A detailed value chain analysis of the industry was conducted. It includes material providers, indirect utility providers, operations & processing, detection & maintenance, and end-users.
• The Competitive dashboard section includes analysis on the basis of Concentration Ratio (CR), based on market size and market presence of key companies.

Key Takeaways from the Global Molecular FISH Testing Market Report:

• Based on technology, the cryo FISH segment holds the highest market share in 2021 and is estimated to continue its dominance over the projection period. With confocal microscopy, the cryo FISH technique provides increased spatial resolution, increased detection sensitivity, increased probe accessibility, and improved picture contrast.
• In terms of probe type, the whole chromosome segment has the highest share in the Global Molecular FISH Testing Market in 2021. The whole chromosome probes are used for the multi-color FISH and spectral karyotyping. It is a mixture of probes that binds to the entire chromosome length and thus different chromosomes are colored or labeled with different colored probes.
• Based on cellular stains, DAPI (4,6-diamidino-2-phenylindole) segment has the highest market share in 2021 as the use of DAPI labeling permits cells to be used several times, obviating the requirement for duplicate samples.
• In terms of application, the cancer research segment holds the highest market share in 2021 and registers the highest CAGR over the projection period. This is due to the rising prevalence of cancer across the globe. Further, FISH testing has been used to detect and better predict the course and treatment of various cancers, including lung cancer, brain cancer, ovarian cancer, colon cancer, melanoma, and others.
• The clinical segment is the highest end-user segment in the molecular FISH testing market in 2021, whereas companion diagnostics have the highest CAGR over the forecast period. This is because FISH is used to diagnose congenital diseases such as Down's Syndrome and Edward's Syndrome.
• North America holds the highest share in the Global Molecular FISH Testing Market in 2021 and is further expected to continue its dominance across the projection period. This is due to the rising incidence of cancer and infectious diseases in the region.

Competitive Insight

The key players in the Global Molecular FISH Testing Market are Thermo Fisher, Abbott Laboratories, Agilent, Oxford Gene Technology, and ARUP Laboratories, among others. Through extensive research, it is found that big players have adopted various competitive strategies such as mergers & acquisitions in order to have a grip on the emerging markets. Furthermore, leading companies are expanding their geographical boundaries by acquiring small brands and domestic companies.

Segmentation Overview

The following are the different segments of the Global Molecular FISH Testing Market:

By Technology segment of the Global Molecular FISH Testing Market is sub-segmented into:

• Flow FISH
• Q FISH
• Immuno FISH
• Cryo FISH
• Other FISH

By Probe Type segment of the Global Molecular FISH Testing Market is sub-segmented into:

• Locus specific
• Centromeric repeats
• Whole chromosome

By Cellular Stains segment of the Global Molecular FISH Testing Market is sub-segmented into:

• DAPI (4,6-diamidino-2-phenylindole)
• Acridine Orange
• Others

By Application segment of the Global Molecular FISH Testing Market is sub-segmented into:

• Cancer Research
  • Lung
  • Breast
  • Bladder
  • Haematological
  • Gastric
  • Prostrate
  • Cervical
  • Other
• Genetic Diseases
• Other

By End User segment of the Global Molecular FISH Testing Market is sub-segmented into:

• Research
• Clinical
• Companion diagnostics

By Region segment of the Global Molecular FISH Testing Market is sub-segmented into:

• North America
  • The U.S.
  • Canada
  • Mexico
• Europe
  • Western Europe
    • The U.K.
    • Germany
    • France
    • Italy
    • Spain
    • Rest of Western Europe
  • Eastern Europe
    • Poland
    • Russia
    • Rest of Eastern Europe
• Asia Pacific 
  • China
  • India
  • Japan
  • Australia & New Zealand
  • ASEAN
  • Rest of Asia Pacific
• Middle East & Africa
  • UAE
  • Saudi Arabia
  • South Africa
  • Rest of the Middle East & Africa
• South America
  • Argentina
  • Brazil
  • Rest of South America